Accession Number : AD1039423


Title :   Cellular Therapy to Obtain Rapid Endochondral Bone Formation


Descriptive Note : Technical Report,01 Feb 2007,31 Jan 2008


Corporate Author : Baylor College of Medicine Houston United States


Personal Author(s) : Olmsted-Davis,Elizabeth A ; Davis,Alan R ; Heggeness,Michael ; West ,Jennifer ; Gannon,Francis ; Hipp,John ; Olabisi, Ronke ; Dickinson,Mary ; Wada,Aya


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1039423.pdf


Report Date : 01 Feb 2008


Pagination or Media Count : 32


Abstract : This project, on the use of cell-based gene therapy for the production of rapid endochondral bone formation, and fracture healing is a collaborative effort between a bioengineering/biomaterials group at Rice University and Baylor College of Medicine. Although bone possesses the rare capacity to continually renew and repair itself, more than 500,000 bone repair surgical procedures are performed annually within the United States alone. The need to enhance orinitiate bone formation in a controlled clinical manner has brought tissue engineering to the forefront of orthopedic research. Much recent effort has been directed to the identification of factors essential to normal bone formation, and the development of new osteoconductive materials that can temporarily fill areas of missing osteoid. Still lacking are effective osteoinductive components that could be seeded into the osteoconductive materials to generate normal bone which this study will explore. The central hypothesis of this application is that rapid bone formation can be successfully achieved with only minimally invasive percutaneous techniques and without a scaffold, by using cells transduced with adenovirus vectors to express an osteoinductive factor (BMP2), which have been encapsulated in hydrogel material and later photopolymerized at the desired site.


Descriptors :   bone and bones , osteogenesis , bone diseases , peptide growth factors , confocal microscopy , adipocytes , bone marrow , gene therapy , orthopedics , antibacterial agents , immune system , therapeutics , cell line , stem cells , stromal cells , proteins , surgical procedures


Subject Categories : Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE