Accession Number : AD1039078


Title :   ENZYME-CATALYZED MUTATION IN BREAST CANCER


Descriptive Note : Technical Report,01 Aug 2013,31 Jul 2015


Corporate Author : UNIVERSITY OF MINNESOTA TWIN CITIES Minneapolis United States


Personal Author(s) : Harris,Reuben S


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1039078.pdf


Report Date : 01 Oct 2015


Pagination or Media Count : 47


Abstract : The development of breast cancer, including late stage events such as metastasis and drug resistance, requires mutations. The origins of most of these mutations are unknown. We recently implicated the DNA cytosine deaminase APOBEC3B. This Idea Award studies tests the hypothesis that APOBEC3B causes a genome wide hypermutable state and the hypothesis that APOBEC3B alters the epigenome by cytosine deamination and methyl-cytosine deamination mechanisms, respectively. Positive results will be significant because they will delineate a major source of mutations and epigenetic changes in breast cancer, and thereby pave the way for new diagnostic/prognostic tests and methods to treat breast cancer by preventing the activity of this enzyme.


Descriptors :   breast cancer , drug resistance , METASTASIS , genomic instability , genetics , EPIGENETICS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE