Accession Number : AD1037816


Title :   The Development of Nitroxide Based Coatings for Biofilm Remediation- 154020


Descriptive Note : Technical Report,08 Sep 2015,07 Mar 2017


Corporate Author : QUEENSLAND UNIVERSITY OF TECHNOLOGY Brisbane Australia


Personal Author(s) : Fairfull-Smith,Kathryn


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1037816.pdf


Report Date : 05 Jun 2017


Pagination or Media Count : 8


Abstract : In this research, the PI initially aimed to investigate the chemistry of nitroxides within biofilms in order to understand the mechanism by which nitroxides inhibit and disperse biofilms. The PIs then planned to develop new anti-biofilm agents based on nitroxides, explore the application of new chemistries for the immobilisation of nitroxides to relevant substrates and evaluate the effects of these function alised scaffolds on biofilm growth. The PI have synthesized a water soluble profluorescent nitroxide for biofilm imaging. This nitroxide was shown to eradicate an existing biofilm in conjunction with antibiotic use, with excellent results, indicating that these compounds are good targets for future research. Additional research shows that the surface binding nitroxides are most likely inactive, suggesting that the anti-biofilm actions is intracellular. The research resulted in 1 peer reviewed publication, 3 conference presentations, and 1 manuscript in progress. They also have an excellent collaboration with AFRL/RX (Wendy Goodson) and will continue to work on testing compounds provided by this research.


Descriptors :   BIOMATERIALS , antiinfective agents , x ray photoelectron spectroscopy , coatings , storage tanks , antifungal agents , BIOFUELS , fungi , substrates


Subject Categories : Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE