Accession Number : AD1037368


Title :   Host Gene Expression Analysis in Sri Lankan Melioidosis Patients


Descriptive Note : Journal Article


Corporate Author : usamriid Ft detrick United States


Personal Author(s) : Natesan,Mohan ; Krishnananthasivam,Shivankari ; Jayathilaka,Nimanthi ; Sathkumara,Harindra D ; Corea,Enoka ; De Silva,Aruna D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1037368.pdf


Report Date : 19 Jun 2017


Pagination or Media Count : 42


Abstract : Melioidosis is a life threatening infectious disease caused by the gram-negative bacillus Burkholderia pseudomallei predominantly found in southeast Asia and northern Australia. Studying the host transcription profiles in response to infection is crucial for understanding disease pathogenesis and correlates of disease severity, which may help improve therapeutic intervention and survival. The aim of this study was to analyze gene expression levels of human host factors in melioidosis patients and establish useful correlation with disease biomarkers, compared to healthy individuals and patients with sepsis caused by other pathogens.


Descriptors :   GRAMNEGATIVE BACTERIAL INFECTIONS , melioidosis , infectious diseases , gene expression , therapeutics , biological markers , sepsis


Subject Categories : Microbiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE