Accession Number : AD1036927


Title :   Antibiotic Resistance In Neisseria Gonorrhoeae: Impact Of Ceftriaxone Resistance On Microbial Fitness And Potential Of Resistance Determinants To Spread During Mixed Infection


Descriptive Note : Technical Report


Corporate Author : Uniformed Services University of the Health Sciences Bethesda United States


Personal Author(s) : Vincent,Leah R


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1036927.pdf


Report Date : 07 Mar 2016


Pagination or Media Count : 190


Abstract : Approximately 106 million cases of gonorrhea occur worldwide each year, and antibiotic treatment is critical for control. However, the rapid evolution of drug resistance in Neisseria gonorrhoeae (Gc) threatens this strategy. Extended-spectrum cephalosporins (ESC), including ceftriaxone (Cro), are the last remaining monotherapy for gonorrhea. Increasing resistance of Gc to the ESCs has amplified the threat of untreatable gonorrhea. Cro resistance in Gc is conferred primarily by mosaic penA alleles that encode multiple amino acid substitutions within penicillin-binding protein 2 (PBP 2).


Descriptors :   GONORRHEA , antibacterial agents , cell physiological processes , fungi , bacterial infections , stress (physiology) , antiinfective agents , coinfection , genetic variation , liquid chromatography , metabolism , polymeric films , proteomics , culture techniques , cellular structures


Subject Categories : Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE