Accession Number : AD1036792


Title :   Regulation of Polysaccharide- and Protein- Specific Antibody Responses to Intact Extracellular Bacteria


Descriptive Note : Technical Report


Corporate Author : Uniformed Services University of the Health Sciences Bethesda United States


Personal Author(s) : Kar,Swagata


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1036792.pdf


Report Date : 11 Mar 2016


Pagination or Media Count : 126


Abstract : Many studies have been published detailing the mechanisms of antibody production in response to bacterial polysaccharides (PS) and proteins, either in soluble, isolated form and/or as conjugate vaccines composed of an immunogenic carrier protein covalently linked to PS. However, much less is knownregarding antibody responses to PS and protein expressed naturally by intact extracellular bacteria. We describe two major projects in mice that investigated the mechanism of PS- and/or protein-specific anti-IgG responses to intact, heat-killed Gram-positive and/or Gram-negative bacteria, in comparison to PS- and/or protein-specific IgG responses elicited by isolated PS or protein, and/or conjugate vaccine.


Descriptors :   bacterial infections , vaccines , polysaccharides , Antibodies , Vaccines , Immunity


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE