Accession Number : AD1036479

Title :   Effect of a New Local Anesthetic Buffering Device on Pain Reduction During Nerve Block lnjections

Descriptive Note : Technical Report

Corporate Author : Uniformed Services University of the Health Sciences Bethesda United States

Personal Author(s) : Comerci,Andrew W

Full Text :

Report Date : 10 Jul 2014

Pagination or Media Count : 18

Abstract : The purpose of this double-blind, split-mouth, randomized human clinical study was to evaluate the effectiveness of a new sodium bicarbonate local anesthetic buffering device (Onset, Onpharma) in reducing pain associated with dental injections. Twenty patients were given bilateral inferior alveolar (IA) and long buccal (LB) nerve block injections and asked to quantify the pain experienced during injection using a visual analog scale (VAS). One side of the mouth received standard of care injections using 2% Lidocaine with 1:100,000 epinephrine. On the opposite side, injections were administered using 2% Lidocaine with 1:100,000 epinephrine buffered 9:1 with 8.4% sodium bicarbonate using the Onset device to mix the components within the anesthetic carpule. A mean VAS score and standard deviation for the IA injection was 2.7 1.3 for buffered and 2.7 1.9 for unbuffered and for the LB injection was 2.0 1.4 for buffered and 2.7 1.8 for unbuffered. The data were analyzed with a paired t-test (alpha=0.05). No significant difference was found between groups for the IA (p=0.94) or the LB injections (p=0.17).Conclusion: Onpharmas Onset local anesthetic buffering technology did not significantly reduce pain from common dental nerve block injections compared to the standard unbuffered injection.

Descriptors :   anesthesia , clinical trials , dentistry , pain , pain management , INJECTIONS (MEDICINE) , mouth , test and evaluation , LOCAL ANESTHETICS , dental equipment , patients , nerve blocking , standard deviation

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE