Accession Number : AD1036327


Title :   The Role of Histone Demethylase Jmjd3 in Immune-Mediated Aplastic Anemia


Descriptive Note : Technical Report,01 Mar 2016,28 Feb 2017


Corporate Author : Temple University of the Commonwealth System Philadelphia United States


Personal Author(s) : Zhang,Yi


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1036327.pdf


Report Date : 01 Mar 2017


Pagination or Media Count : 17


Abstract : Acquired aplastic anemia (AA) is a condition of bone marrow failure (BMF) characterized by blood pancytopenia and BM hypoplasia. In most cases, AA is an immune-mediated disorder with destruction of hematopoietic stem and progenitor cells by T cells. There is increasing evidence that CD4+ T effector cells that produce high levels of IFN- are associated with AA in patients and experimental AA mice. IFN- displays potent effects on suppressing hematopoiesis. Immunosuppressive therapy with antithymocyte globulin in combination with cyclosporin A (CsA) can induce a hematologic response in about two-thirds of AA patients. However, relapse occurs in up to 35% of AA patients when CsA is withdrawn at 6 months. Allogeneic BM transplantation (BMT) has significantly improved the survival of AA. However, graft-versus-host disease (GVHD) remains a major barrier to the success of the procedure. Novel approaches are needed to improve the outcomes of AA treatment.


Descriptors :   Anemias , bone marrow , TRANSPLANTS , stem cells , cell line , therapeutics


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE