Accession Number : AD1036276

Title :   GCMS/MS Analyses of Biological Samples in Support of Evaluation of Toxicity Associated with Intravenous Exposure to VX Stereoisomers in Guinea Pigs

Descriptive Note : Technical Report,01 Jan 2016,31 Aug 2016

Corporate Author : Edgewood Chemical Biological Center Aberdeen Proving Ground United States

Personal Author(s) : McGuire, Jeffrey M ; Wright,Linnzi K ; Kristovich,Robert L ; Busch,Michael W

Full Text :

Report Date : 01 Jul 2017

Pagination or Media Count : 60

Abstract : This report documents the results of the gas chromatography tandem mass spectrometry analyses of blood, tissues, and organs (heart, lung, liver, kidney, and brain) that were obtained from guinea pigs intravenously exposed to various concentrations of O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX) stereoisomers. The amount of O-ethyl methylphosphonofluoridate (VX-G) present in these biological samples was quantified using chemical ionization mass spectrometry with isotope dilution.

Descriptors :   gas chromatography , mass spectrometry , VX AGENT , STEREOISOMERS , exposure (physiology) , toxicity , Pharmacokinetics , sampling , tissues (biology) , blood , ORGANS (ANATOMY)

Subject Categories : Toxicology
      Chemical, Biological and Radiological Warfare

Distribution Statement : APPROVED FOR PUBLIC RELEASE