Accession Number : AD1035806


Title :   Green-Tea and Epigallocatechin-3-Gallate are Bactericidal against Bacillus anthracis


Descriptive Note : Journal Article - Open Access


Corporate Author : USAMRIID Ft Detrick United States


Personal Author(s) : Chua,Jennifer ; Falcinelli,Shane D ; Shi,Maggie C ; Friedlander,Arthur M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1035806.pdf


Report Date : 12 Jun 2017


Pagination or Media Count : 19


Abstract : Bacillus anthracis, the etiological agent of anthrax, is listed as a Category A biothreat agent by the United States Centers for Disease Control and Prevention. The virulence of the organism is due to expression of two exotoxins and capsule, which interfere with host cellular signaling, alter host water homeostasis, and inhibit phagocytosis of the pathogen, respectively. Concerns regarding the past and possible future use of B. anthracis as a bioterrorism agent have resulted in an impetus to develop more effective protective measures and therapeutics. In this study, green tea was found to inhibit the in vitro growth of B. anthracis. Epigallocatechin-3-gallate (EGCG), a compound found abundantly in green tea, was shown to be responsible


Descriptors :   anthrax , bioterrorism , therapeutics , ANTIINFECTIVE AGENTS , antibacterial agents , grampositive bacteria


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE