Accession Number : AD1035796


Title :   Odor-Evoked Inhibition of Olfactory Sensory Neurons Drives Olfactory Perception in Drosophila


Descriptive Note : Journal Article - Open Access


Corporate Author : USAMRIID Frederick


Personal Author(s) : Zeng,Xiankun ; Cao,Li-Hui ; Yang,Dong ; Wu,Wei ; Jing,Bi-Yang ; Li,Meng-Tong ; Qin,Shanshan ; Tang,Chao ; Tu,Yuhai ; Luo,Dong-Gen


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1035796.pdf


Report Date : 07 Nov 2017


Pagination or Media Count : 60


Abstract : Inhibitory response occurs throughout the nervous system, including the peripheral olfactory system. While odor-evoked excitation in peripheral olfactory cells is known to encode odor information, the molecular mechanism and functional roles of odor-evoked inhibition remain largely unknown. Here, we examined Drosophila olfactory sensory neurons (OSNs) and found that inhibitory odors triggered outward receptor currents by reducing the constitutive activities of odorant receptors, inhibiting the basal spike firing in OSNs. Remarkably, this odor-evoked inhibition of OSNs elicited by itself a full range of olfactory behaviors from attraction to avoidance, as did odor-evoked OSN excitation.


Descriptors :   inhibition , nervous system , odors , smell , animal structures , sensory receptor cells


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE