Accession Number : AD1035796

Title :   Odor-Evoked Inhibition of Olfactory Sensory Neurons Drives Olfactory Perception in Drosophila

Descriptive Note : Journal Article - Open Access

Corporate Author : USAMRIID Frederick

Personal Author(s) : Zeng,Xiankun ; Cao,Li-Hui ; Yang,Dong ; Wu,Wei ; Jing,Bi-Yang ; Li,Meng-Tong ; Qin,Shanshan ; Tang,Chao ; Tu,Yuhai ; Luo,Dong-Gen

Full Text :

Report Date : 07 Nov 2017

Pagination or Media Count : 60

Abstract : Inhibitory response occurs throughout the nervous system, including the peripheral olfactory system. While odor-evoked excitation in peripheral olfactory cells is known to encode odor information, the molecular mechanism and functional roles of odor-evoked inhibition remain largely unknown. Here, we examined Drosophila olfactory sensory neurons (OSNs) and found that inhibitory odors triggered outward receptor currents by reducing the constitutive activities of odorant receptors, inhibiting the basal spike firing in OSNs. Remarkably, this odor-evoked inhibition of OSNs elicited by itself a full range of olfactory behaviors from attraction to avoidance, as did odor-evoked OSN excitation.

Descriptors :   inhibition , nervous system , odors , smell , animal structures , sensory receptor cells

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE