Accession Number : AD1035753


Title :   Targeting Transcription Elongation Machinery for Breast Cancer Therapy


Descriptive Note : Technical Report,15 Apr 2016,14 Apr 2017


Corporate Author : University of California, Berkeley Berkeley United States


Personal Author(s) : Luo,Kunxin


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1035753.pdf


Report Date : 01 May 2017


Pagination or Media Count : 16


Abstract : This project focuses on the important but under-studied role of the P-TEFb-dependent transcription elongation machinery in human breast cancer progression. It aims to test the hypothesis that transcription elongation is a key regulatory step in breast cancer development, and that targeting P-TEFb can be an effective strategy to block breast cancer progression. During the current reporting period, we have made significant progress toward the identification of the ELL2-containing SEC as the form of active P-TEFb that plays a key role in promoting breast cancer cell EMT.


Descriptors :   breast cancer , biomedical research , neoplasms , elongation , multiprotein complexes , cells(biology) , metastasis


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE