Accession Number : AD1035753

Title :   Targeting Transcription Elongation Machinery for Breast Cancer Therapy

Descriptive Note : Technical Report,15 Apr 2016,14 Apr 2017

Corporate Author : University of California, Berkeley Berkeley United States

Personal Author(s) : Luo,Kunxin

Full Text :

Report Date : 01 May 2017

Pagination or Media Count : 16

Abstract : This project focuses on the important but under-studied role of the P-TEFb-dependent transcription elongation machinery in human breast cancer progression. It aims to test the hypothesis that transcription elongation is a key regulatory step in breast cancer development, and that targeting P-TEFb can be an effective strategy to block breast cancer progression. During the current reporting period, we have made significant progress toward the identification of the ELL2-containing SEC as the form of active P-TEFb that plays a key role in promoting breast cancer cell EMT.

Descriptors :   breast cancer , biomedical research , neoplasms , elongation , multiprotein complexes , cells(biology) , metastasis

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE