Accession Number : AD1035711


Title :   Prediction of Response to Therapy and Clinical Outcome through a Pilot Study of Complete Genetic Assessment of Ovarian Cancer


Descriptive Note : Technical Report,30 Sep 2012,29 Sep 2015


Corporate Author : Dana-Farber Cancer Institute Boston United States


Personal Author(s) : Matulonis,Ursula


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1035711.pdf


Report Date : 01 Dec 2015


Pagination or Media Count : 12


Abstract : In this project low grade serous cancer, clear cell, endometrioid (low grade and high grade),and mucinous cancers will be interrogated and subjected to somatic mutation profiling using genome sequencing and array comparative genomic hybridization (aCGH) to explore copy number alterations (CNA). To date, over 200subjects have enrolled and pathology has identified blocks for DNA extraction. The Study remains important as nothing has been published on the molecular alternation of the different histological subtypes of ovarian cancer.


Descriptors :   OVARIAN CANCER , histological subtypes , somatic mutations , cancer research , genomics


Distribution Statement : APPROVED FOR PUBLIC RELEASE