Accession Number : AD1035710


Title :   Cell Penetrating Bispecific Antibodies for Targeting Oncogenic Transcription Factors in Advanced Prostate Cancer


Descriptive Note : Technical Report,30 Sep 2012,29 Sep 2016


Corporate Author : Medical University of South Carolina Charleston United States


Personal Author(s) : Lilly,Michael ; Weisbart,Richard


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1035710.pdf


Report Date : 01 Dec 2016


Pagination or Media Count : 12


Abstract : The goal of these studies is to develop and validate cell-penetrating bi-specific antibodies as an agent that can selectively inhibit the function of intracellular proteins. We have developed 3E10-AR441 bi-specific antibody to inhibit the function both ligand-dependent and independent forms of the androgen receptor (AR), key drivers of prostate carcinogenesis.


Descriptors :   prostate cancer , antibodies , inhibition


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE