Accession Number : AD1035710

Title :   Cell Penetrating Bispecific Antibodies for Targeting Oncogenic Transcription Factors in Advanced Prostate Cancer

Descriptive Note : Technical Report,30 Sep 2012,29 Sep 2016

Corporate Author : Medical University of South Carolina Charleston United States

Personal Author(s) : Lilly,Michael ; Weisbart,Richard

Full Text :

Report Date : 01 Dec 2016

Pagination or Media Count : 12

Abstract : The goal of these studies is to develop and validate cell-penetrating bi-specific antibodies as an agent that can selectively inhibit the function of intracellular proteins. We have developed 3E10-AR441 bi-specific antibody to inhibit the function both ligand-dependent and independent forms of the androgen receptor (AR), key drivers of prostate carcinogenesis.

Descriptors :   prostate cancer , antibodies , inhibition

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE