Accession Number : AD1035696


Title :   Prevention of Ovarian High Grade Serous Carcinoma by Elucidating Its Early Changes


Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016


Corporate Author : Johns Hopkins University Baltimore United States


Personal Author(s) : Kurman,Robert J ; Shih,Ie-Ming


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1035696.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 54


Abstract : Project 1: We will determine the early molecular changes in STIC and their biological significance in developing high-grade serous carcinoma. Marker selection and sample preparation will begin in the next coming months. Project 2: We will evaluate whether the presence of a STIC is associated with different clinical manifestations and/or outcome compare to those patients in whom a STIC was not identified. Molecular profiling will be initiated after quality control checking. Project 3: We will identify the early molecular changes that precede the development of STICs using gene expression analysis of morphologically normal FTE from high-risk women compared to FTE from normal control specimens and use an in vitro system and a mouse model to generate a molecularly defined carcinoma resembling HGSC from FTE and OSE using oncogenes expressed in ovarian carcinoma. Project 4: We plan to if the statin drugs are effective in preventing STIC formation and suppress tumor progression in the OVGP1 mouse model that spontaneously develops STIC and neoplasms. Project 5: With the data and cases piling up, we will be able to address the molecular and epidemiologic profile of putative precursor lesions including STIC in the fallopian tubes and ovaries from women at high-risk for ovarian cancer. Also, a pilot study will be performed to determine the most cost-effective way to prepare the tissue sections for studies related to study early tumor development in ovarian cancer. This information will be shared with science community.


Descriptors :   ovarian cancer , mutations , biological markers


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE