Accession Number : AD1035531


Title :   Treatment of Early Post-Op Wound Infection after Internal Fixation


Descriptive Note : Technical Report,15 Sep 2015,14 Sep 2016


Corporate Author : Vanderbilt University Medical Center Nashville United States


Personal Author(s) : Obremskey,William


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1035531.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 5


Abstract : Severe fractures are common in modern warfare with fractures being fixed via internal fixation of plates and screws to hold the fracture stable while the bone heals. Approximately 10%-40% of severe fractures fixed with internal fixation develop a deep wound infection during the healing process. Thus, the overall goals of this study are to (1) evaluate the effect of treatment of post-op wound infection in long bones after fracture fixation or joint fusion and either: (Group 1) operative debridement and PO antibiotic treatment for 6 weeks; or (Group 2) operative debridement and IV antibiotics for 6 weeks and (2) build and validate a risk prediction model for failure of treatment of early postoperative wound infections after fixation of fractures or joint fusion.


Descriptors :   BONE FRACTURES , wound infections , therapeutics , antibacterial agents , drug therapy , debridement , orthopedic surgical procedures


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE