Accession Number : AD1035012

Title :   Kevlar Vest Protection against Blast Overpressure Brain Injury: Systemic Contributions to Injury Etiology

Descriptive Note : Technical Report,01 May 2008,30 Jul 2015

Corporate Author : The Geneva Foundation Tacoma United States

Personal Author(s) : Long,Joseph B

Full Text :

Report Date : 01 Jul 2015

Pagination or Media Count : 158

Abstract : The etiology of blast-induced traumatic brain injury (TBI) is largely undefined. Along with reducing mortality, in preliminary experiments Kevlar vests significantly protected against BOP-induced neuropathological changes in rats. We postulate that: 1) much of the blast-induced fiber degeneration in brain results from pressure surges transmitted through the vasculature that elicit a series of intracranial disruptions, and 2) Kevlar vests are neuroprotective by uncoupling this pressure significant contribution of the effects of blast on the thorax to brain injury. These studies will provide critical insights into the etiology of blast-induced brain injury, transmission following exposure to blast. Using a compression driven shock tube, we compare external, systemic (e.g. vascular arterial and venous), and central (e.g. intracranial pressure) BOP-induced pressure changes, and assess the impact of Kevlar vests on these changes. We seek to: 1) determine if measured pressure changes are blast severity-dependent and correspond with outcome measures, and 2)assess the impact of Kevlar vests on measured BOP-induced pressure changes and outcome measures and establish whether a protective vest encasing the thorax ameliorates blast-induced brain injury, pointing to a and will advance the development of mitigation strategies.

Descriptors :   brain injuries , trauma , blast injuries , blast , OVERPRESSURE , PROTECTIVE CLOTHING , ETIOLOGY , rats , pressure , shock tubes , THORAX

Subject Categories : Medicine and Medical Research
      Protective Equipment

Distribution Statement : APPROVED FOR PUBLIC RELEASE