Accession Number : AD1034410


Title :   Collective Genetic Interaction Effects and the Role of Antigen Presenting Cells in Autoimmune Diseases


Descriptive Note : Journal Article


Corporate Author : Biotechnology High Performance Computing Software Applications Institute Frederick United States


Personal Author(s) : Woo,Hyungg Jun ; Yu,Chenggang ; Reifman,Jaques


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1034410.pdf


Report Date : 12 Jan 2017


Pagination or Media Count : 27


Abstract : Autoimmune diseases occur when immune cells fail to develop or lose their tolerance toward self and destroy body's own tissues. Both insufficient negative selection of self-reactiveT cells and impaired development of regulatory T cells preventing effector cell activation are believed to contribute to autoimmunity. Genetic predispositions center around the major histocompatibility complex (MHC) class II loci involved in antigen presentation, the keydeterminant of CD4+ T cell activation. Recent studies suggested that variants in the MHCregion also exhibit significant non-additive interaction effects. However, collective interactions involving large numbers of single nucleotide polymorphisms (SNPs) contributing to such effects are yet to be characterized. In addition, relatively little is known about the celltype-specificity of such interactions in the context of cellular pathways. Here, we analyzed type 1 diabetes (T1D) and rheumatoid arthritis (RA) genome-wide association data sets vialarge-scale, high-performance computations and inferred collective interaction effects involving MHC SNPs using the discrete discriminant analysis.


Descriptors :   autoimmune diseases , genomics , genetics , antigens , immune system , genetic variation


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE