Accession Number : AD1034093


Title :   Effects of Radiation on the Microbiota and Intestinal Inflammatory Disease


Descriptive Note : Technical Report,31 Aug 2015,30 Aug 2016


Corporate Author : Cedars-Sinai Medical Center Los Angeles United States


Personal Author(s) : Underhill,David ; Shiao,Stephen


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1034093.pdf


Report Date : 01 Sep 2016


Pagination or Media Count : 16


Abstract : In this annual report (covering initiating and collaborating PI projects) we report the completion of initial experiments investigating the effect of whole body and focal (GI tract) irradiation of mice on the bacterial and fungal microbiota. We have identified substantial changes in intestinal microbial communities induced by both types of radiation exposure. In particular, specific fungal community changes appear to be pronounced and relatively long-lived. As outlined in the project proposal, we are now embarking on experiments aimed a evaluating the effects of these changes on intestinal susceptibility to inflammatory disease.


Descriptors :   radiation , colitis , cancer , GASTROINTESTINAL TRACT , fungi , BACTERIA , inflammation


Subject Categories : Medicine and Medical Research
      Radiobiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE