Accession Number : AD1034085


Title :   Localizing and Assessing Amputee Pain with Intense Focused Ultrasound


Descriptive Note : Technical Report,15 Sep 2015,14 Sep 2016


Corporate Author : University of Washington, Dept. of Neurological Surgery Seattle United States


Personal Author(s) : Mourad,Pierre D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1034085.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 34


Abstract : Here we propose exploratory studies to stimulate subcutaneous pain generators in patients within residual limbs using research image-guided intense focused ultrasound (ig-iFU) system. Out targets for iFU stimulation include neuromas, intact nerves, TMR (targeted muscle reinnervation) sites, and patient-identified 'sensitive areas'. Successful application of iFU to deep, potentially painful tissue should allow us to locate that tissue and compare their relative sensitivity to external stimulation. This would be consistent with our preliminary human data. Also, our rat studies suggest it plausible that painful tissue in humans would require less ultrasound to generate a sensation than surrounding tissue. We specifically anticipate that we will show that TMR sites are less sensitive than neuromas. This and our questionnaire studies will support the view that TMR surgery may reduce amputee pain relative to standard amputation surgery.


Descriptors :   AMPUTATION , ULTRASONICS , PAIN , amputees , tissues , questionnaires , TRANSDUCERS , residual limbs


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE