Accession Number : AD1034085

Title :   Localizing and Assessing Amputee Pain with Intense Focused Ultrasound

Descriptive Note : Technical Report,15 Sep 2015,14 Sep 2016

Corporate Author : University of Washington, Dept. of Neurological Surgery Seattle United States

Personal Author(s) : Mourad,Pierre D

Full Text :

Report Date : 01 Oct 2016

Pagination or Media Count : 34

Abstract : Here we propose exploratory studies to stimulate subcutaneous pain generators in patients within residual limbs using research image-guided intense focused ultrasound (ig-iFU) system. Out targets for iFU stimulation include neuromas, intact nerves, TMR (targeted muscle reinnervation) sites, and patient-identified 'sensitive areas'. Successful application of iFU to deep, potentially painful tissue should allow us to locate that tissue and compare their relative sensitivity to external stimulation. This would be consistent with our preliminary human data. Also, our rat studies suggest it plausible that painful tissue in humans would require less ultrasound to generate a sensation than surrounding tissue. We specifically anticipate that we will show that TMR sites are less sensitive than neuromas. This and our questionnaire studies will support the view that TMR surgery may reduce amputee pain relative to standard amputation surgery.

Descriptors :   AMPUTATION , ULTRASONICS , PAIN , amputees , tissues , questionnaires , TRANSDUCERS , residual limbs

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE