Accession Number : AD1033982


Title :   Ex Vivo Machine Perfusion in VCA with a Novel Oxygen Carrier System to Enhance Graft Preservation and Immunologic Outcomes


Descriptive Note : Technical Report,15 Sep 2013,14 Sep 2016


Corporate Author : University of Pittsburgh Pittsburgh United States


Personal Author(s) : Fontes,Paulo


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1033982.pdf


Report Date : 01 Dec 2016


Pagination or Media Count : 62


Abstract : The objective of this proposal is to establish the graft preservation and immunomodulatory effects of our MP-BMPS/HBOC system in a pre-clinical large animal CTA model. We will specifically address the following specific aims in a porcine vascularized musculo-adipo-cutaneous flap model: Aim 1: Does MP-BMPS/HBOC allow prolongation of CIT without significant cellular damage to the allograft? Aim 2: Does the MP-BMPS/HBOC minimize the effects and incidence of ischemia-reperfusion injury at revascularization? Aim 3: What is the effect of MP-BMPS/HBOC on the immune profile of various flap tissues after transplantation?


Descriptors :   transplants , Ischemia , Preservation , cytokines , metabolomics


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE