Accession Number : AD1033982

Title :   Ex Vivo Machine Perfusion in VCA with a Novel Oxygen Carrier System to Enhance Graft Preservation and Immunologic Outcomes

Descriptive Note : Technical Report,15 Sep 2013,14 Sep 2016

Corporate Author : University of Pittsburgh Pittsburgh United States

Personal Author(s) : Fontes,Paulo

Full Text :

Report Date : 01 Dec 2016

Pagination or Media Count : 62

Abstract : The objective of this proposal is to establish the graft preservation and immunomodulatory effects of our MP-BMPS/HBOC system in a pre-clinical large animal CTA model. We will specifically address the following specific aims in a porcine vascularized musculo-adipo-cutaneous flap model: Aim 1: Does MP-BMPS/HBOC allow prolongation of CIT without significant cellular damage to the allograft? Aim 2: Does the MP-BMPS/HBOC minimize the effects and incidence of ischemia-reperfusion injury at revascularization? Aim 3: What is the effect of MP-BMPS/HBOC on the immune profile of various flap tissues after transplantation?

Descriptors :   transplants , Ischemia , Preservation , cytokines , metabolomics

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE