Accession Number : AD1033973


Title :   Educating Normal Breast Mucosa to Prevent Breast Cancer


Descriptive Note : Technical Report,24 Apr 2015,09 Sep 2016


Corporate Author : Mayo Clinic Jacksonville Jacksonville United States


Personal Author(s) : Knutson,Keith L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1033973.pdf


Report Date : 01 Dec 2016


Pagination or Media Count : 13


Abstract : Breast cancer develops from breast mucosa and breast mucosa has intact immune system to maintain epithelial integrity. In this study our goal was to study the immune subsets associated with breast mucosa and develop the strategies to populate mucosa with immune effectors in order to prevent breast cancer. Data obtained from our studies suggest that T cells constitute the majority of immune cells in breast mucosa and this includes conventional CD4 T cells, CD8+ T cells and significant fraction of unconventional double positive (DP) CD4+CD8+ T cells. We also observed that intramammary immunization induces antigen-specific immune responses in breast mucosa. Currently, studies are being done to characterize these double positive T cells to determine whether these are regulatory or cytotoxic in nature and their roles in prevention of breast cancer. In addition to this, we are also investigating the ability of intramammary immunization in prevention of breast cancer and the feasibility of translating this approach into preventive breast cancer vaccine setting.


Descriptors :   breast cancer , immune system , immunization , vaccines , therapeutics


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE