Accession Number : AD1033898


Title :   FES-Rowing versus Zoledronic Acid to Improve BoneHealth in SCI


Descriptive Note : Technical Report,30 Sep 2010,29 Sep 2016


Corporate Author : Spaulding Rehabilitation Hospital Boston United States


Personal Author(s) : Morse,Leslie R


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1033898.pdf


Report Date : 01 Dec 2016


Pagination or Media Count : 9


Abstract : There is no established treatment to prevent bone loss or to induce new bone formation following SCI, although the risk is high in this population of osteoporosis-related bone fracture. This study aims to learn if the severe osteoporosis in lower extremities caused by spinal cord injuries can be slowed or reversed with a combination of an exercise that simulates weight-bearing and a bisphosphonate medication. 70Individuals with T3-12 spinal cord injuries will be enrolled in a 12-month regime of adapted FES-rowing. Our preliminary study findings demonstrated this exercise led to new bone formation and improved bone micro architecture in the lower extremities of people with SCI. Half of the subjects also receive a bisphosphonate medication known to slow bone loss, but not stimulate bone renewal. Participant recruitment began in late February, 2011, and was completed in October 2013. We have enrolled 70 subjects, 46 of whom have completed the study. Data analysis was completed February 2017.


Descriptors :   bone fractures , lower extremity , osteogenesis , musculoskeletal physiology , bone diseases , therapeutics , xray computed tomography , finite element analysis , clinical trials , infusions , spinal injuries , EXERCISE (PHYSIOLOGY)


Subject Categories : Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE