Accession Number : AD1033779


Title :   Developing Novel Therapeutic Approaches in Small Cell Lung Carcinoma Using Genetically Engineered Mouse Models and Human Circulating Tumor Cells


Descriptive Note : Technical Report,15 Sep 2013,14 Sep 2016


Corporate Author : Massachusetts General Hospital Boston United States


Personal Author(s) : Engelman,Jeffrey


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1033779.pdf


Report Date : 01 Dec 2016


Pagination or Media Count : 49


Abstract : We have successfully developed mouse models in which to perform in vivo experiments, as well as developed expertise in live animal imaging to enable monitoring to tumors over time in these models. We have initiated treatment studies with chemotherapy and with targeted therapies in our models. Our preliminary data indicate that tumor response to chemotherapy in our models is modest. However, we find that tumor response to combination targeted therapy is significantly superior to either targeted therapy alone or to no treatment. Correlative biomarker studies are underway, including the isolation and enumeration of circulating tumor cells from SCLC patients. These findings support further development of this combination therapy approach and we anticipate ongoing experiments to assess correlative biomarkers.


Descriptors :   health services , cell physiological processes , therapeutics , carcinoma , cell line , chemotherapy , neoplasms , molecules , myeloid cells , linear regression analysis , biomedical research , breakpoint temperature , cultured cells , gene expression , carcinoma


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE