Accession Number : AD1033675

Title :   Harnessing Neuroplasticity to Promote Rehabilitation: CI Therapy for TBI

Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author : University of Alabama at Birmingham Birmingham United States

Personal Author(s) : Taub,Edward ; Uswatte,Gitendra

Full Text :

Report Date : 01 Oct 2016

Pagination or Media Count : 42

Abstract : This study will evaluate Constraint-Induced Movement (CI) therapy for promoting motor recovery in veterans and civilians with traumatic brain injury (TBI). This form of physical rehabilitation has been shown to substantially improve motor function after brain injury not due to trauma and to provoke a widespread neuroplastic response in the brain. This study (N =80) is a single blind, randomized controlled trial that compares CI therapy for improving use of the more-affected arm in adults with TBI to a holistic fitness program named Lakeshore Enriched Fitness Training (LEFT). In addition to assessing changes from pre-treatment in more-affected arm motor function at post-treatment and 1-year afterwards, changes will be examined in white matter, grey matter, and functional brain activity. Products at the end of the first year of this blinded study are a manual of procedures and a method for generating synthetic neuroimaging data for the purpose of evaluating the sensitivity of the techniques proposed for quantifying changes in grey matter.

Descriptors :   brain injuries , therapeutics , military personnel , Weapons effects , neuroplasticity , clinical trials , neuroimaging , physical therapy , Arms(Anatomy) , hands , UPPER EXTREMITY , traumatic stress disorder

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE