Accession Number : AD1033404


Title :   Genetic Variations in SLCO Transporter Genes Contributing to Racial Disparity in Aggressiveness of Prostate Cancer


Descriptive Note : Technical Report,15 Sep 2015,14 Sep 2016


Corporate Author : Health Research, Inc. Buffalo United States


Personal Author(s) : Wu,Yue


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1033404.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 30


Abstract : The proposed studies are expected to (1) identify genetic variations in the genes of androgen transporters that are associated with the racial differences in prostate cancer aggressiveness; (2) identify key androgen transporters of which the expression and/or the alteration of expression in cancer relative to benign prostate tissue are associated with racial differences in prostate cancer aggressiveness. Progress in the reporting period includes: 1) Completion of genotyping for all 11 SLCO members using PCaP DNA samples; 2) Finish data processing and preliminary data analyses for genotyping, and identified SNPs that may be associated with prostate cancer characteristics; 3) Continued RNAScope analysis of SLCO transporter in prostate cancer tissue sections and discover unique cell type-specific expression of a SLCO transporter; 4) Further delineation of androgen uptake mechanism on molecular levels.


Descriptors :   prostate cancer , african americans , androgens , GENETIC VARIATION , deoxyribonucleic acids , epidemiology , gene expression , ribonucleic acids


Subject Categories : Medicine and Medical Research
      Genetic Engineering and Molecular Biology


Distribution Statement : APPROVED FOR PUBLIC RELEASE