Accession Number : AD1033280


Title :   Primary Blast Injury Criteria for Animal/Human TBI Models using Field Validated Shock Tubes


Descriptive Note : Technical Report,15 Aug 2015,14 Aug 2016


Corporate Author : New Jersey Institute of Technology Newark United States


Personal Author(s) : Chandra,Namas ; Skotak,Maciej


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1033280.pdf


Report Date : 01 Sep 2016


Pagination or Media Count : 28


Abstract : Injury severity in blast induced Traumatic Brain Injury (bTBI) increases with blast overpressure (BOP) and impulse in dose-dependent manner. Pure primary blast waves were simulated in compressed gas shock-tubes in discrete increments. We evaluated 24 hour survival of rats in 0-450 kPa (0-800 Pas impulse) range at 10 discrete levels (60, 100, 130, 160, 190, 230, 250, 290, 350 and 420 kPa) and determined the mortality rate as a non-linear function of BOP. Using logistic regression model, predicted mortality rate (PMR) function was calculated, and used to establish TBI severities. We determined a BOP of 145 kPa as upper mild TBI threshold (5 % PMR). Also we determined 146-220 kPa and 221-290 kPa levels as moderate and severe TBI based on 35%, and 70% PMR, respectively, while BOP above 290 kPa is lethal.


Descriptors :   blast injuries , brain injuries , overpressure , shock tubes , blast waves , rats , REGRESSION ANALYSIS , models , heart rate , biological markers , trauma , stress (physiology) , simulations


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology
      Test Facilities, Equipment and Methods


Distribution Statement : APPROVED FOR PUBLIC RELEASE