Accession Number : AD1033262


Title :   Targeting Trypsin-Inflammation Axis for Pancreatitis Therapy in a Humanized Pancreatitis Model


Descriptive Note : Technical Report,15 Sep 2015,14 Sep 2016


Corporate Author : Cedars-Sinai Medical Center Los Angeles United States


Personal Author(s) : Pandol,Stephen J ; Lugea,Aurelia


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1033262.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 9


Abstract : Acute pancreatitis especially due to alcohol and smoking goes onto chronic pancreatitis which, in turn, is a risk factor for pancreatic cancer. Because only a relatively small portion of patients with alcohol abuse and smoking develop pancreatitis, it is very likely that there are genetic underlying predisposing factors that have not been discovered that explain why certain individuals develop pancreatitis. A genetic defect in the trypsinogen gene (PRSS1 gene) causing hereditary pancreatitis is now well established. We developed a transgenic mouse using a Bacterial Artificial Chromosome harboring the full-length human PRSS1 with the key mutation of hereditary pancreatitis (PRSS1R122H). During the funding year we used this novel mouse model to determine whether PRSS1R122H predispose to pancreatitis. Our data so far indicates that mice expressing PRSS1R122H develop a more severe form of pancreatitis than wild type mice controls. We are working now in understanding the mechanisms underlying the observed effects.


Descriptors :   pancreatitis , ALCOHOLISM , TOBACCO SMOKING , trypsinogen , genes , MUTATIONS , mice , models , gene expression


Subject Categories : Medicine and Medical Research
      Genetic Engineering and Molecular Biology


Distribution Statement : APPROVED FOR PUBLIC RELEASE