Accession Number : AD1033114

Title :   Microenvironments and Signaling Pathways Regulating Early Dissemination, Dormancy, and Metastasis

Descriptive Note : Technical Report,01 Sep 2015,31 Aug 2016

Corporate Author : Albert Einstein College of Medicine Bronx United States

Personal Author(s) : Condeelis,John ; Aguirre-Ghiso,Julio

Full Text :

Report Date : 01 Sep 2016

Pagination or Media Count : 6

Abstract : We devoted effort to both aims, to optimize methods and publish the first phase of efforts. SA1 is to understand the intrinsic mechanisms of dissemination by early-progressed cancer cells and how the microenvironment in these primary sites named P-TMEM (Primary Tumor Microenvironment of Metastases) contribute to early dissemination. We now have new data suggesting that a signature of early dissemination markers consisting on HER2HI/p-ATF2LO/E-cadhLO could identify motile early-progressed tumor cells and predict for dissemination. We further show that mammary tissue macrophages and HER2HI/p-ATF2LO/E-cadhLO tumor cells cooperate to disseminate early.

Descriptors :   biological staining and labeling , blood vessels , epithelial cells , breast cancer , bone marrow , neoplasms , macrophages , inhibitors , cells (biology) , Metastasis

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE