Accession Number : AD1033114


Title :   Microenvironments and Signaling Pathways Regulating Early Dissemination, Dormancy, and Metastasis


Descriptive Note : Technical Report,01 Sep 2015,31 Aug 2016


Corporate Author : Albert Einstein College of Medicine Bronx United States


Personal Author(s) : Condeelis,John ; Aguirre-Ghiso,Julio


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1033114.pdf


Report Date : 01 Sep 2016


Pagination or Media Count : 6


Abstract : We devoted effort to both aims, to optimize methods and publish the first phase of efforts. SA1 is to understand the intrinsic mechanisms of dissemination by early-progressed cancer cells and how the microenvironment in these primary sites named P-TMEM (Primary Tumor Microenvironment of Metastases) contribute to early dissemination. We now have new data suggesting that a signature of early dissemination markers consisting on HER2HI/p-ATF2LO/E-cadhLO could identify motile early-progressed tumor cells and predict for dissemination. We further show that mammary tissue macrophages and HER2HI/p-ATF2LO/E-cadhLO tumor cells cooperate to disseminate early.


Descriptors :   biological staining and labeling , blood vessels , epithelial cells , breast cancer , bone marrow , neoplasms , macrophages , inhibitors , cells (biology) , Metastasis


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE