Accession Number : AD1033113

Title :   Microenvironments and Signaling Pathways Regulating Early Dissemination, Dormancy, and Metastasis

Descriptive Note : Technical Report,01 Sep 2015,31 Aug 2016

Corporate Author : Mount Sinai School of Medicine New York, United States

Personal Author(s) : Aguirre-Ghiso,Julio ; Condeelis,John

Full Text :

Report Date : 01 Sep 2016

Pagination or Media Count : 99

Abstract : We devoted effort to both aims, to optimize methods and publish the first phase of efforts. SA1 is to understand the intrinsic mechanisms of dissemination by early-progressed cancer cells and how the microenvironment in these primary sites named P-TMEM (Primary Tumor Microenvironment of Metastases) contribute to early dissemination. We now have new data suggesting that a signature of early dissemination markers consisting on HER2HI/p-ATF2LO/E-cadhLO could identify motile early-progressed tumor cells and predict for dissemination. We further show that mammary tissue macrophages and HER2HI/p-ATF2LO/E-cadhLO tumor cells cooperate to disseminate early.

Descriptors :   macrophages , peptide growth factors , breast cancer , culture techniques , epithelial cells , stem cells , biological factors , confocal microscopy , blood cells , metastasis

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE