Accession Number : AD1033045


Title :   Integration of Peptides into Organic Thin Film Transistor (OTFT)-based Printable Sensors


Descriptive Note : Technical Report,22 Apr 2015,21 Oct 2016


Corporate Author : UNIVERSITY OF NEWCASTLE RESEARCH SERVICES GRANTS OFFICE CALLAGHAN Australia


Personal Author(s) : Dastoor, Paul ; Belcher,Warwick J ; Zhou,Xiaojing


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1033045.pdf


Report Date : 10 Feb 2017


Pagination or Media Count : 15


Abstract : Biosensors based on organic thin film transistor technology offer the exciting prospect of detecting and identifying peptides; biomarkers found in bodily fluids. This development would assist in the monitoring or identification of medical diseases and facilitate rapid, point-of-care testing. In particular, neuropeptide Y is a highly abundant neurotransmitter with links to many important physiological functions, including stress response. Its rapid detection provides an opportunity to identify anxiety and stress related disorders such as post-traumatic stress disorder. Moreover, inkjet printing of organic electronic inks may provide a pathway for reliable, large scale production of low cost sensors. In this project, multiple detection mechanisms for two different peptides, L-reduced glutathione and neuropeptide Y, are presented. A pathway for impedance-based peptide detection using Nafion films was also presented. Receptor elements for glutathione detection were incorporated into the sensor device structure and a current response three times larger than that of water was obtained when 2 mM glutathione was placed on the sensor. This response demonstrated an increase in sensitivity of five times over the non-transistor based sensing mechanism. Electrochemical detection of neuropeptide Y was also achieved, with the method proposed, utilising monoclonal anti-neuropeptide Y antibodies, enabling detection of neuropeptide Y concentrations below 95 nM.


Descriptors :   BIOSENSORS , thin film transistors , self assembled monolayers , AMINO ACIDS , PEPTIDES , AND PROTEINS , semiconductors , stress (physiology) , thin films , chemical reactions , BIOLOGICAL MARKERS , MULTISENSORS , PRINTING , liquid chromatography , mass spectrometry , traumatic stress disorder


Subject Categories : Biomedical Instrumentation and Bioengineering
      Electrical and Electronic Equipment


Distribution Statement : APPROVED FOR PUBLIC RELEASE