Accession Number : AD1032853


Title :   Delivery of Nanotethered Therapies to Brain Metastases of Primary Breast Cancer Using a Cellular Trojan Horse


Descriptive Note : Technical Report,15 Sep 2013,14 Sep 2016


Corporate Author : Northwestern University Evanston United States


Personal Author(s) : Clare,Susan E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1032853.pdf


Report Date : 01 Dec 2016


Pagination or Media Count : 65


Abstract : The purpose of this work is to utilize monocyte/macrophage-enabled delivery, a novel therapeutic delivery system that we pioneered, to increase the effectiveness and decrease the toxicity of the treatment of intracranial metastases from primary breast cancer. Our objective in this proposal is to deliver therapeutics to brain metastases using a nanoshell(NS)-double-stranded DNA (dsDNA)-drug complex loaded within monocytes/macrophages. Once present within the metastasis, we aim to release the drug by transcranial irradiation at near-infrared (NIR) wavelengths. Our studies have provided fundamental information on a number of aspects of the delivery of therapeutics by NS and NSdsDNA. 1. DNA duplexes are released from the nanoshell surface differently depending on type of laser. 2. Hydrophobic therapeutics can be complexed to nanoshells using protein scaffolds. 3. The amount and distribution of near infrared (NIR) light able to be delivered through the skull and brain tissue have been estimated. 4. The use of CT to map skull geometry and determine bone density enables a better understanding of the attenuation/scattering of NIR.


Descriptors :   xray computed tomography , breast cancer , monte carlo method , central nervous system , metallic nanoparticles , refractive index , near infrared radiation , therapeutics , brain tumors , DIAGNOSTIC IMAGING


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE