Accession Number : AD1032301


Title :   Quantification of Tetramethylenedisulfotetramine (TETS) in Various Food Matrices by Solid Phase Extraction Liquid ChromatographyIon Trap Mass Spectrometry


Descriptive Note : Technical Report,01 Mar 2012,01 Jun 2012


Corporate Author : Edgewood Chemical Biological Center Aberdeen Proving Ground United States


Personal Author(s) : Bae,Sue Y ; Kong,Li


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1032301.pdf


Report Date : 01 Apr 2017


Pagination or Media Count : 38


Abstract : Tetramethylenedisulfotetramine (TETS), commonly known as tetramine, is a highly neurotoxic rodenticide (the LD50, or lethal dose for 50 of test subjects, is 0.1 mg/kg). TETS has been used in hundreds of deliberate and accidental food poisoning events in China. In this report, we describe an extraction method for the quantitation of TETS as spiked into various food matrices, including fruit juices, egg, hot dog, chicken nuggets, turkey deli meat, and ground beef. Quantitation by liquid chromatographyion trap mass spectrometry was based upon selected reaction monitoring of mass-to-charge ratio (m/z) 347 268 and consecutive reaction monitoring of m/z 347268175. An 5 mg TETS concentration was spiked into each food sample. The linear range of quantitation for TETS was 0.520 g/mL. Total recoveries (and percent relative standard deviations) for TETS in various food samples are reported.


Distribution Statement : APPROVED FOR PUBLIC RELEASE