Accession Number : AD1031940


Title :   Optimization of Soft Tissue Management, Spacer Design, and Grafting Strategies for Large Segmental Bone Defects using the Chronic Caprine Tibial Defect Model


Descriptive Note : Technical Report,30 Sep 2013,29 Sep 2016


Corporate Author : MINNESOTA UNIV MINNEAPOLIS MINNEAPOLIS United States


Personal Author(s) : Pluhar,G E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1031940.pdf


Report Date : 01 Dec 2016


Pagination or Media Count : 41


Abstract : This proposal addresses the treatment of segmental bone defects and methods that can be used to manipulate the Masquelet induced membrane to create a graft bed that optimizes bone regeneration. The effect of surgical management of the IM demonstrated a significant benefit of scraping to remove the inner layer of the IM (p=0.041).In contrast, modifying the texture on the PMMA spacer to double the surface area of the IM did not result in improved bone regeneration. This finding can be immediately translated into clinical practice. This study high lights the fact that the Chronic Caprine Tibial Defect Model is sufficiently sensitive to detect variations and represents a suitable clinically relevant animal model for testing new therapies for bone regeneration.


Descriptors :   connective tissue , cartilage , bone and bones , SURGERY , tibia , bone regeneration


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE