Accession Number : AD1031691


Title :   High Infection Rates in Adult Macaques Following Intravaginal or Intrarectal Zika Virus Inoculation


Descriptive Note : Journal Article - Embargoed Full-Text


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD FORT DETRICK United States


Personal Author(s) : Haddow,Andrew D ; Nalca,Aysegul ; Rossi,Franco D ; Miller,Lynn J ; Wiley,Michael R ; Perez-Sautu,Unai ; Washington,Samuel C ; Norris,Sarah L ; Wollen-Roberts,Suzanne E ; Shamblin,Joshua D ; Kimmel,Adrienne E ; Bloomfield,Holly A ; Valdez,Stephanie M ; Sprague,Thomas R ; Principe,Lucia M ; Bellanca,Stephanie A ; Cinkovich,Stephanie S ; Lugo-Roman,Luis ; Cazares,Lisa H ; Pratt,William D ; Palacios,Gustavo F ; Bavari,Sina ; Pitt,Margaret L ; Nasar,Farooq


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1031691.pdf


Report Date : 07 Apr 2017


Pagination or Media Count : 22


Abstract : Unprotected sexual intercourse between persons residing in or traveling from regions with Zika virus transmission is a risk factor for infection. To model risk for infection after sexual intercourse, we inoculated rhesus and cynomolgus macaques with Zika virus by intravaginal or intrarectal routes. In macaques inoculated intravaginally, we detected viremia and virus RNA in 50% of macaques, followed by seroconversion. In macaques inoculated intrarectal, we detected viremia, virus RNA, or both, in 100% of both species, followed by seroconversion. The magnitude and duration of infectious virus in the blood of macaques suggest humans infected with Zika virus through sexual transmission will likely generate viremias sufficient to infect competent mosquito vectors. Our results indicate that transmission of Zika virus by sexual intercourse might serve as a virus maintenance mechanism in the absence of mosquito-to-human transmission and could increase the probability of establishment and spread of Zika virus in regions where this virus is not present.


Descriptors :   health services , virus diseases , viruses , infectious diseases , biomedical research , biological sciences , vaccines , tropical medicine , laboratory animals , infection , immune serums , wound infections , sodium compounds , body weight , biochemistry , animals , amino acids , antibodies , arbovirus INFECTIONS , MOSQUITO BORNE DISEASES , SEX , INFECTION , viruses


Subject Categories : Microbiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE