Accession Number : AD1031640


Title :   Synergic Investigation Of The Self-Assembly Structure And Mechanism Of Retroviral Capsid Proteins By Solid State NMR, Transmission Electron Microscopy And Multiscale simulation


Descriptive Note : Technical Report,15 Mar 2013,14 Sep 2016


Corporate Author : University Of Central Florida Orlando United States


Personal Author(s) : Chen,Bo


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1031640.pdf


Report Date : 29 Mar 2017


Pagination or Media Count : 26


Abstract : The Rous Sarcoma Virus (RSV) is the ideal platform to study retrovirus. The RSV capsid enclosing the viral genome materials is assembled from 1500 copies of the 237-residue RSV capsid protein (CA). In vitro, tubular assembly can be obtained with the CA with similar underlying structural properties as the authentic RSV capsid. Due to strong polymorphism, RSV CA assemblies are challenging for structural characterization by techniques such as X-ray diffraction or cryo Electron Microscopy (cryo-EM).


Descriptors :   electron microscopy , self assembly , retroviruses , proteins


Subject Categories : Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE