Accession Number : AD1031450


Title :   Tumor Associated Neutrophils in Human Lung Cancer


Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016


Corporate Author : Trustees of the University of Pennsylvania Philadelphia United States


Personal Author(s) : Eruslanov,Evgeniy


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1031450.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 114


Abstract : The role of tumor-associated neutrophils (TANs) in cancer progression remains unclear and has only been recently investigated in murine tumor models. However, there are limited data about the TANs in human tumor. The goal of this study is to provide a phenotypic and functional characterization of TANs in lung cancer patients. We have identified two major subsets of TANs in lung tumors: canonical TANs that express classic neutrophil markers and APC-like hybrid TANs that display a combination of canonical neutrophil markers and markers of antigen-presenting cells. In this study we have performed analysis of key inflammatory factors secreted by canonical and hybrid neutrophils. We have also performed whole human genome RNA expression profiles of these neutrophil subsets. We found that the APC-like hybrid neutrophils are superior to canonical neutrophils in their ability to trigger and support T cell responses in direct cell-cell interactions.


Descriptors :   lung cancer , immune system , tumor cell line , neoplasms


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE