Accession Number : AD1031293

Title :   Drosophila as a Screening Platform for Novel Lung Cancer Therapeutics

Descriptive Note : Technical Report,01 Sep 2015,31 Aug 2016

Corporate Author : Icahn School of Medicine at Mount Sinai New York United States

Personal Author(s) : Cagan,Ross L

Full Text :

Report Date : 01 Sep 2016

Pagination or Media Count : 27

Abstract : The research in this grant is designed to explore the effects of genetic and genomic complexity in lung cancer progression and response to therapeutics. Using Drosophila, we are establishing a set of personalized fly lines, each which represents a separate patient. In this Progress Report, I discuss our initial studies in building these lines. In addition, I discuss our results with screening a library of 1200 FDA approved drugs. We provide evidence that a two drug cocktail, trametinib plus fluvastatin, synergize to improve efficacy and minimize toxicity in fly and human cell line models.

Descriptors :   lung cancer , therapeutics , genetics , genomics , cell line , drug combinations , drug therapy

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE