Accession Number : AD1031293


Title :   Drosophila as a Screening Platform for Novel Lung Cancer Therapeutics


Descriptive Note : Technical Report,01 Sep 2015,31 Aug 2016


Corporate Author : Icahn School of Medicine at Mount Sinai New York United States


Personal Author(s) : Cagan,Ross L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1031293.pdf


Report Date : 01 Sep 2016


Pagination or Media Count : 27


Abstract : The research in this grant is designed to explore the effects of genetic and genomic complexity in lung cancer progression and response to therapeutics. Using Drosophila, we are establishing a set of personalized fly lines, each which represents a separate patient. In this Progress Report, I discuss our initial studies in building these lines. In addition, I discuss our results with screening a library of 1200 FDA approved drugs. We provide evidence that a two drug cocktail, trametinib plus fluvastatin, synergize to improve efficacy and minimize toxicity in fly and human cell line models.


Descriptors :   lung cancer , therapeutics , genetics , genomics , cell line , drug combinations , drug therapy


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE