Accession Number : AD1031284


Title :   Development of Dietary Polyphenol Preparations for Treating Veterans with Gulf War Illness


Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016


Corporate Author : Icahn School of Medicine at Mount Sinai New York United States


Personal Author(s) : Pasinetti,Giulio


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1031284.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 24


Abstract : There are no treatments for Gulf War Illness (GWI) and there is an urgent need to develop novel interventions either to resolve underlying GWI mechanisms, or to alleviate major GWI clinical complications, particularly chronic fatigue, cognitive difficulties, muscle pain, as well as mood disturbances and sleep problems. Recent evidence from our group and from others revealed that certain dietary flavonoids may promote cognitive function and/or alleviate chronic fatigue. We hypothesized that dietary supplementation with a Flavonoid Rich Preparation (FRP), a combination of Concord Grape Juice (CGJ) and Grape Seed Polyphenolic Extract (GSPE) may help alleviate clinical complications of GWI, particularly chronic fatigue and/or cognitive dysfunction. We propose to test the feasibility of dietary supplementation with FRP in Veterans with GWI, and to gather evidence supporting the efficacy of FRP in alleviating GWI-associated cognitive deficits and chronic fatigue.


Descriptors :   veterans health , PERSIAN GULF SYNDROME , military medicine , patient care management , department of veterans affairs , clinical trials , delivery of health care , therapeutics , questionnaires , mental processes , pain , muscles , FATIGUE (PHYSIOLOGY) , SLEEP DISORDERS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE