Accession Number : AD1031185


Title :   Candidate Medical Countermeasures Targeting Ebola Virus Cell Entry


Descriptive Note : Technical Report


Corporate Author : USAMRIID Frederick United States


Personal Author(s) : Liang,Janie ; Jangra,Rohit K ; Radoshitzky,Sheli R ; Wada,Jiro ; Bollinger,Laura ; Chandran,Kartik ; Kuhn,Jens H ; Jensen,Kenneth S


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1031185.pdf


Report Date : 31 Mar 2017


Pagination or Media Count : 35


Abstract : Medical countermeasures against virus infections ideally prevent the adsorption or entry of virions into target cells, thereby circumventing infection. Recent significant advances in elucidating the mechanism of Ebola virus (EBOV) host-cell penetration include the involvement of two-pore channels at the early stage of entry, and identification of cellular proteases for EBOV spike glycoprotein maturation and the intracellular EBOV receptor, NPC1. This improved understanding of the initial steps of EBOV infection is now increasingly applied to rapid development of candidate medical countermeasures, some of which have already entered the clinic. In this review, we summarize the currently known spectrum of EBOV cell entry inhibitors, describe their mechanism of action, and their potential for future development.


Descriptors :   virus diseases , viral hemorrhagic fevers , antiviral agents , therapeutics , cells(biology) , ebola virus , filoviridae , cellular structures


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE