Accession Number : AD1031110


Title :   Cognitive Impairment in MS Linked to Structural and Functional Connectivity


Descriptive Note : Technical Report,29 Sep 2015,28 Sep 2016


Corporate Author : The Research Foundation of State University Stony Brook United States


Personal Author(s) : Krupp,Lauren


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1031110.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 12


Abstract : Multiple sclerosis (MS) is the most common progressive neurologic disorder to occur in adults of working-age. Pathologically, MS is characterized by demyelination, immune-mediated inflammation and neurodegeneration within the central nervous system (CNS). Cognitive impairment is estimated to occur in up to 70 of all patients. In this study, the measure of cognitive impairment used, called intra-individual variability (IIV), can detect variability in each subjects performance over time. This is a sensitive indicator of cognitive impairment in individuals with neurological disorders including MS. Multiple types of brain imaging will be used to acquire data from participants, including Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET). Data from the first 10 subjects in each cohort has been acquired, pre-processed and both raw data and image analysis outputs have been put through extensive quality control/assurance analysis. The significance of our preliminary findings suggest we may be able to uncover early biological underpinnings of cognitive impairment, which could both improve our understanding of MS and help in the development of novel therapeutics for this impairment.


Descriptors :   magnetic resonance imaging , positron emission tomography , sclerosis , neuroimaging , autoimmune disease


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE