Accession Number : AD1030538

Title :   Role of Activin A in Immune Response to Breast Cancer

Descriptive Note : Technical Report,15 Nov 2015,14 Nov 2016

Corporate Author : Weill Cornell Medical College New York United States

Personal Author(s) : Vanpouille-Box,Claire I

Full Text :

Report Date : 01 Dec 2016

Pagination or Media Count : 12

Abstract : Owing to its ability to spread systematically, breast cancer remains a life-threatening tumor. Therefore, efforts in developing new treatment strategies are needed in order to eradicate metastatic breast cancer. In this respect, the activation of the immune system to elicit anti-tumor immune responses represents one of the most promising approaches that have recently demonstrated some success in other diseases. However, clinically apparent tumors have already harnessed host mechanisms to prevent immune activation and to induce an immunosuppressive microenvironment hindering immunotherapy-based treatments. As a consequence, the immune system fails to recognize cancer cells as dangerous and actively suppresses anti-tumor immune responses.

Descriptors :   breast cancer , neoplasms , immune system , immunotherapy , metastasis , radiotherapy , IMMUNOSUPPRESSION

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE