Accession Number : AD1030538


Title :   Role of Activin A in Immune Response to Breast Cancer


Descriptive Note : Technical Report,15 Nov 2015,14 Nov 2016


Corporate Author : Weill Cornell Medical College New York United States


Personal Author(s) : Vanpouille-Box,Claire I


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1030538.pdf


Report Date : 01 Dec 2016


Pagination or Media Count : 12


Abstract : Owing to its ability to spread systematically, breast cancer remains a life-threatening tumor. Therefore, efforts in developing new treatment strategies are needed in order to eradicate metastatic breast cancer. In this respect, the activation of the immune system to elicit anti-tumor immune responses represents one of the most promising approaches that have recently demonstrated some success in other diseases. However, clinically apparent tumors have already harnessed host mechanisms to prevent immune activation and to induce an immunosuppressive microenvironment hindering immunotherapy-based treatments. As a consequence, the immune system fails to recognize cancer cells as dangerous and actively suppresses anti-tumor immune responses.


Descriptors :   breast cancer , neoplasms , immune system , immunotherapy , metastasis , radiotherapy , IMMUNOSUPPRESSION


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE