Accession Number : AD1030129


Title :   Molecular Epidemiology Investigation of Obesity and Lethal Prostate Cancer


Descriptive Note : Technical Report,01 Sep 2014,31 Oct 2016


Corporate Author : Harvard T. H. Chan School of Public Health Boston United States


Personal Author(s) : Ebot,Ericka


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1030129.pdf


Report Date : 01 Jan 2017


Pagination or Media Count : 103


Abstract : The major objective of the PCRP postdoctoral training award was to provide training and opportunities for the principal investigator (PI) to further her development as an independent prostate cancer researcher in the field of molecular epidemiology. During the award period the PI performed research incorporating tissue-level biomarker data into epidemiologic studies of prostate cancer progression to investigate the relationship between obesity, the tumor microenvironment, and lethal prostate cancer. Using whole transcriptome gene expression profiling data, she identified several gene signature enriched in the tumor tissue of overweight and obese prostate cancer patients. Furthermore, several of these signatures were associated with poor prognosis. The findings supported an epigenetic link between obesity and prostate cancer survival which will be explored in future studies. The support of the award has provided many opportunities to enhance the professional development of the PI. The coursework and research activities accomplished over the past two years have strengthened her research skills. The PI has presented her research at a number of meetings and conferences and has submitted a manuscript of the findings from this award. During this period she has developed new collaborations that have led to exciting new research opportunities.


Descriptors :   prostate cancer , body weight , gene expression , epidemiology Obesity , inflammation , neoplasms


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE