Accession Number : AD1030124


Title :   A Novel Animal Model for Investigating the Neural Basis of Focal Dystonia


Descriptive Note : Technical Report,01 Sep 2015,31 Aug 2016


Corporate Author : The Research Foundation of State University Stony Brook


Personal Author(s) : Evinger,Leslie


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1030124.pdf


Report Date : 01 Sep 2016


Pagination or Media Count : 15


Abstract : The overall goal of the project was to develop an animal model of the focal dystonia benign essential blepharospasm. Consistent with the widely held view that dystonia results from an interaction between a predisposing condition and an environmental trigger, we proposed to use7 Hz deep brain stimulation of the basal ganglia as the predisposing condition and dry eye as an environmental trigger. Based on experiments during the 1st year of the grant, our publication, Evinger, J. Neuro-Ophthalmol. 35:374-379, 2015 demonstrated the feasibility of this approach. In addition, we began important control experiments and preliminary recordings from the superior colliculus.


Descriptors :   eye diseases , movement disorders , central nervous system


Subject Categories : Medicine and Medical Research
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE