Accession Number : AD1029641


Title :   Molecular Profiling of Intraductal Carcinoma of the Prostate


Descriptive Note : Technical Report,30 Sep 2013,29 Sep 2016


Corporate Author : Johns Hopkins University Baltimore United States


Personal Author(s) : Lotan,Tamara L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1029641.pdf


Report Date : 01 Dec 2016


Pagination or Media Count : 43


Abstract : Defined by the presence of malignant cells spreading within intact prostatic ducts and acini, intraductal carcinoma of the prostate (IDC-P) occurs almost exclusively in high Gleason grade and stage tumors and is a consistent independent risk factor for tumor progression and death. Importantly, however, IDC-P is currently systematically under-diagnosed in needle biopsies because it has significant morphologic overlap with another intraepithelial lesion, high grade prostatic intraepithelial neoplasia (HGPIN). We hypothesize that IDC-P represents progression of invasive high-risk prostate carcinoma, and thus is molecularly distinct from HGPIN. Herein, we have conducted an unbiased, three-pronged set of experiments to definitively identify the molecular signature of IDC-P using a combination of protein, RNA, and DNA-based assays.


Descriptors :   Prostate cancer , gene expression , statistical analysis , therapeutics , tissues biology , biological detection , magnetic resonance , multivariate analysis , epithelial cells , neoplasms


Distribution Statement : APPROVED FOR PUBLIC RELEASE