Accession Number : AD1028493


Title :   Aldehyde Recognition and Discrimination by Mammalian Odorant Receptors via Functional Group-Specific Hydration Chemistry


Descriptive Note : Journal Article


Corporate Author : CUNY - City College of New York New York United States


Personal Author(s) : Li,Yadi ; Peterlin,Zita ; Ho,Jianghai ; Yarnitzky,Tali ; Liu,Min T ; Fichman,Merav ; Niv,Masha Y ; Matsunami,Hiroaki ; Firestein,Stuart ; Ryan,Kevin


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1028493.pdf


Report Date : 02 Sep 2015


Pagination or Media Count : 12


Abstract : The mammalian odorant receptors (ORs) form a chemical-detecting interface between the atmosphere and the nervous system. This large gene family is composed of hundreds of membrane proteins predicted to form as many unique small molecule binding niches within their G-protein coupled receptor (GPCR) framework, but very little is known about the molecular recognition strategies they use to bind and discriminate between small molecule odorants.


Descriptors :   aldehydes , fluorescence , molecular biology , cell physiological processes , membrane proteins , hydrogen bonds , fluorine , biological products , proteins , luminescence , computational modeling , fluorescent dyes


Distribution Statement : APPROVED FOR PUBLIC RELEASE