Accession Number : AD1028483


Title :   In Vivo Measurement of Drug Efficacy in Breast Cancer


Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016


Corporate Author : MASSACHUSETTS GENERAL HOSPITAL BOSTON United States


Personal Author(s) : Giedt,Randy J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1028483.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 20


Abstract : The focus of this project is to understand how nano-encapsulated formulations of common chemotherapies work in vivo by developing and utilizing intravital methods for studying drug and nanoparticle function in mouse breast cancer models. We hypothesize that, firstly, we can develop longitudinal breast cancer specific methods of imaging common chemotherapies and their nanoparticle equivalents. Secondly, we hypothesize that encapsulated drugs will be more effective in terms of specific cell responses as they achieve longer exposure times than unencapsulated drugs. Overall, this work will result in the creation of a breast cancer centered platform for drug development and analysis. At the clinical level, this study will result in pertinent data regarding several agents currently in clinical trials. At the basic science level, we will work to understand the heterogeneity of cell responses to drug treatments. Thus, we believe this project has potential impact in both the near and long term for breast cancer treatment.


Descriptors :   breast cancer , systems biology , free radicals , chemotherapy , clinical trials , epithelial cells , Pharmacokinetics , nanoparticles , IMAGING TECHNIQUES


Distribution Statement : APPROVED FOR PUBLIC RELEASE