Accession Number : AD1024756


Title :   Identification of Novel Drug Targets and Lead Compounds for Advanced Prostate Cancer through Genomic and Cheminformatic Analyses


Descriptive Note : Technical Report,01 Aug 2014,31 Jul 2016


Corporate Author : University of British Columbia Vancouver Canada


Personal Author(s) : Hsing,Michael


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1024756.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 50


Abstract : Prostate cancer (PCa) is one of the most common cancers for males in the United States and Canada. When PCa is diagnosed early, it can be treated by surgery or radiation. However, inabout 30 of cases when PCa recurs or metastasizes, the disease is managed primarily by hormone therapy. Unfortunately, the effectiveness of this therapy is temporary due to emerging resistance mechanisms.


Descriptors :   prostate cancer , gene expression , biological factors , central nervous system , fatty acids , proteins , bioassay , therapeutics , cell physiological processes , tissues , amino acids , genomics , computer aided design , proteomics , TRANSCRIPTION GENETICS , INHIBITORS


Distribution Statement : APPROVED FOR PUBLIC RELEASE