Accession Number : AD1024106


Title :   Stress and PTSD Mechanisms as Targets for Pharmacotherapy of Alcohol Abuse, Addiction and Relapse


Descriptive Note : Technical Report,30 Sep 2015,29 Sep 2016


Corporate Author : Seattle Institute for Biomedical and Clinical Research Seattle United States


Personal Author(s) : Rasmussen,Dennis


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1024106.pdf


Report Date : 01 Oct 2016


Pagination or Media Count : 30


Abstract : We have demonstrated that (1) alcohol-nave rats exhibiting high acoustic startle response which is sequent associated with increased anxiety-like behavior) develop increased subsequent alcohol intake and preference which are highly correlated with acoustic startle amplitude determined before the initial access to alcohol, providing a prospective index of vulnerability to developing alcohol abuse, as well as insights into mechanism.


Descriptors :   TRAUMATIC STRESS DISORDER , ANXIETY DISORDERS , PREVENTIVE MEDICINE , THERAPY , ALCOHOLIC BEVERAGES , ethanols , drug abuse , receptor sites (physiology) , physiological effects , response (biology)


Distribution Statement : APPROVED FOR PUBLIC RELEASE