Accession Number : AD1023979


Title :   EF5 PET of Tumor Hypoxia: A Predictive Imaging Biomarker of Response to Stereotactic Ablative Radiotherapy (SABR) for Early Lung Cancer


Descriptive Note : Technical Report,15 Aug 2015,14 Sep 2016


Corporate Author : Leland Stanford Junior University Stanford United States


Personal Author(s) : Loo,Billy Jr W


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/1023979.pdf


Report Date : 01 Sep 2016


Pagination or Media Count : 10


Abstract : Stereotactic ablative radiotherapy (SABR) has become a new standard of care for early stage lung cancer in patients who are not candidates for surgery because of excessive surgical risk, and will be an important treatment option for a growing segment of patients with lung cancer. This is particularly true as lung cancer screening efforts are expected to diagnose a greater proportion of lung cancers at earlier stages, yet the aging of the population will lead to a greater proportion of patients that increase surgical risk. Tumor hypoxia is a major known mechanism of radiation resistance and is especially expected to affect very short courses of radiation as in SABR. Imaging using a third generation hypoxia PET agent, 18F-EF5, is a promising approach for noninvasive hypoxia measurement that needs to be validated in the clinical setting.


Descriptors :   Lung cancer , therapeutics , radiotherapy , neoplasms , hypoxia , radiation resistance , measurement , biological markers , intervention , DIAGNOSTIC IMAGING , cancer research , Positron emission tomography


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE